探究右美托咪定（Dex）对腹股沟疝手术麻醉效果及安全性的影响。

采用前瞻性研究，纳入皖南医学院第二附属医院2020年1月至2022年10月收治的60例行腹股沟疝手术患者。通过随机数字表法将其分为A、B 2组，每组均为30例，2组患者均给予相同的麻醉诱导，A组在麻醉诱导前静脉泵注0.9%氯化钠注射液，B组静脉泵注右美托咪定（Dex），术中维持用药。对比2组患者麻醉效果、不同时间点血流动力学[心率、平均动脉压（MAP）]情况、氧化应激指标[超氧化物歧化酶（SOD）、丙二醛]，统计不良反应发生情况。

B组麻醉总有效率（93.33%）较A组（73.33%）更高（P<0.05）；2组入室时（T₀）、麻醉诱导前（T₁）心率、MAP对比差异无统计学意义（P>0.05）；与T₀、T₁时刻相比，2组建立气腹时（T₂）、手术完成时（T₃）心率、MAP均下降，且T₃上述指标低于T₂（P<0.05）；B组T₂、T₃时刻心率、MAP低于A组（P<0.05）；术前，2组患者血清SOD及丙二醛水平比较差异无统计学意义（P>0.05），麻醉苏醒后，2组患者血清SOD水平均下降，丙二醛水平均升高（P<0.05）；麻醉苏醒后B组血清SOD水平高于A组，丙二醛水平低于A组（P<0.05）；A、B组不良反应总发生率分别为10.00%（3/30）、13.33%（4/30），差异无统计学意义（χ²=0.162，P>0.05）。

Dex在腹股沟疝手术中具有良好的麻醉效果，可稳定术中血流动力学，减少氧化应激反应，且安全性良好。

To explore the influences of dexmedetomidine (Dex) on anesthesia effect and safety in inguinal hernia surgery.

Using prospective research, a total of 60 patients undergoing inguinal hernia surgery in the Second Affiliated Hospital of Wannan Medical College from January 2020 to October 2022 were enrolled. According to the random number table method, they were divided into groups A and B, with 30 cases in each group. Before and during anesthesia induction, group A was given an intravenous injection of 0.9% sodium chloride, while group B was given an intravenous injection of Dex. The anesthesia effect, hemodynamic indexes [heart rate (HR), mean arterial pressure (MAP)] and oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA)] in the two groups were compared. The occurrence of adverse reactions was statistically analyzed.

The total response rate of anesthesia in group B was higher than that in group A (93.33% vs 73.33%, P<0.05). Immediately after entering the room (T₀) and before anesthesia induction (T1), there was no significant difference in HR or MAP between the two groups (P>0.05). Compared with those at T₀ and T₁, HR and MAP were decreased in both groups immediately after pneumoperitoneum establishment (T₂) and after surgery (T₃), and the above indexes at T₃ were lower than those at T₂ (P<0.05). At T₂ and T₃, HR and MAP in group B were lower than those in group A (P<0.05). Before surgery, there was no significant difference in levels of serum SOD and MDA between the two groups (P>0.05). After anesthesia recovery, SOD was decreased, while MDA was increased in both groups (P<0.05). After anesthesia recovery, the level of serum SOD in group B was higher than that in group A, while the MDA level was lower than that in group A (P<0.05). There was no significant difference in total incidence of adverse reactions between group A and group B [10.00% (3/30) vs 13.33% (4/30), χ²=0.162, P>0.05].

Dex has a good anesthesia effect in inguinal hernia surgery, which can stabilize intraoperative hemodynamics and reduce the oxidative stress response, with good safety.