Research progress of polypropylene and its modified hernia mesh

doi:10.3877/cma.j.issn.1674-392X.2025.02.006

Abstract

Abstract:

Abdominal external hernia is a common surgical disease, and mesh implantation is the main treatment.Polypropylene and its modified mesh have excellent mechanical properties and deformation resistance and are the most widely used repair materials.However, due to its inherent chronic inflammatory response, it may lead to abdominal adhesion, mesh infection, mesh erosion and other complications.Once complications such as mesh infection occur, complex secondary operations are often required to remove the mesh, causing a serious burden to patients and society.Therefore, in order to reduce the occurrence of postoperative complications, various new types of mesh based on polypropylene modification have become a research hotspot.The purpose of this paper is to review the advantages and disadvantages of polypropylene and its modified mesh so as to provide some reference for the personalized selection of clinical mesh.

Key words: Herniorrhaphy, Polypropylene mesh, Hernia repair material, Synthetic materials

Haonan Huang, Fuxin Tang, Ning Ma, Enmin Huang, Tao Ma, Chuangxiong Liu, Taicheng Zhou. Research progress of polypropylene and its modified hernia mesh[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(02): 150-154.

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References 37

[1]	Marcolin P, Oliveira Trindade B, Bueno Motter S, et al.The impact of smoking on inguinal hernia repair outcomes: a meta-analysis of multivariable-adjusted studies[J].Hernia, 2024, 28(5): 2037-2038.
[2]	Huang Y, Zheng D, Zhou Z, et al.The research advances in Kirsten rat sarcoma viral oncogene homolog(KRAS) -related cancer during 2013 to 2022: a scientometric analysis[J].Front Oncol, 2024, 14:1345737.
[3]	Lichtenstein IL, Shulman AG, Amid PK, et al.The tension-free hernioplasty[J].Am J Surg, 1989, 157(2): 188-193.
[4]	王伟刚, 俞永江.疝补片材料学的现状和展望[J].中国普外基础与临床杂志, 2022, 29(4): 556-560.
[5]	孙立, 陈杰, 申英末.国产新型生物疝修补片与聚丙烯产品在腹股沟疝修补术中的疗效对比[J/OL].中华疝和腹壁外科杂志(电子版), 2019, 13(2): 101-104.
[6]	陈松耀, 戴伟钢, 陈创奇.生物补片在疝与腹壁外科的临床应用进展[J/OL].中华疝和腹壁外科杂志(电子版), 2018, 12(2): 90-93.
[7]	Rosen MJ, Bauer JJ, Harmaty M, et al.Multicenter, prospective,longitudinal study of the recurrence, surgical site infection, and quality of life after contaminated ventral hernia repair using biosynthetic absorbable mesh[J].Ann Surg, 2017, 265(1): 205-211.
[8]	陈柳莹, 张杰, 贾忠, 等.腹壁疝补片的应用现状及展望[J].医学研究杂志, 2018, 47(5): 18-22.
[9]	王芳.生物补片材料在盆底功能重建中的应用[J].中国组织工程研究, 2012, 16(25): 4719-4726.
[10]	方斌, 杨福全.腹壁疝修补材料学研究进展[J].中国实用外科杂志, 2015, 35(11): 1247-1250.
[11]	Shankaran V, Weber DJ, Reed RL 2nd, et al.A review of available prosthetics for ventral hernia repair[J].Ann Surg, 2011, 253(1):16-26.
[12]	范中宝, 沈建芬, 王键, 等.3Dmax 轻量型疝补片和Prolene 重量型网片腹膜前修补腹股沟疝的比较[J].中国组织工程研究, 2020,24(34): 5545-5551.
[13]	Wolf MT, Carruthers CA, Dearth CL, et al.Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response[J].J Biomed Mater Res A, 2014, 102(1): 234-246.
[14]	Deveci CD, Öberg S, Rosenberg J.Definition of Mesh Weight and Pore Size in Groin Hernia Repair: A Systematic Scoping Review of Randomised Controlled Trials[J].J Abdom Wall Surg, 2023, 2:11179.
[15]	Kaida D, Miyata T, Kin R, et al.Laparoscopic intraperitoneal mesh repair of a large incisional hernia in a kidney transplantation patient:A case report[J].Asian J Endosc Surg, 2022, 15(1): 180-183.
[16]	Fuziy RA, Artigiani Neto R, Caetano Junior EM, et al.Comparative study of four different types of intraperitoneal mesh prostheses in rats.Acta Cir Bras, 2019, 34(7): e201900703.
[17]	Soda T, Kiuchi H, Koida Y, et al.Transvaginal Polytetrafluoroethylene Mesh Surgery for Pelvic Organ Prolapse: One-Year Safety and Efficacy Results[J].Urology, 2024, 186: 131-138.
[18]	黄亮, 余壮明, 李军, 等.自固定聚丙烯/聚乳酸复合补片改善腹股沟疝无张力修补后的慢性疼痛[J].中国组织工程研究, 2018,22(6): 908-913.
[19]	Ezzat GM, Meki AMA, Meligy FY, et al.Antiapoptotic and chemotaxis-stimulating effects of poly(D, L-lactide-co-glycolide)-chitosan and whey proteins against aflatoxicosis-induced splenic and thymic atrophy[J].Mol Biol Rep, 2023, 50(12): 9805-9824.
[20]	张永祥, 李娇娇, 欧思敏, 等.浸涂法制备聚乳酸乙醇酸共聚物/聚丙烯腹壁复合补片的体外降解及力学性能[J].高分子材料科学与工程, 2020, 36(12): 123-128, 136.
[21]	葛芬芬, 林静, 胡慧洁, 等.羊膜基质/聚丙烯复合补片的制备及其生物相容性评价[J].中国生物医学工程学报, 2020, 39(3):380-384.
[22]	Xiao Y, Zuo X, Li H, et al.Impact of titanium-coated polypropylene mesh on functional outcome and quality of life after inguinal hernia repair[J].Heliyon, 2023, 9(7): e17691.
[23]	杨硕, 刘雨辰, 王明刚, 等.钛涂层复合补片与普通聚丙烯补片在腹腔镜腹股沟疝修补术中效果的前瞻性随机对照研究[J].首都医科大学学报, 2018, 39(2): 299-303.
[24]	Hu H, Sun H, Jiang Z, et al.Study on repair of abdominal wall defect rats with hernia mesh coated with chitosan-based photosensitive hydrogel[J].Carbohydr Polym, 2022, 291: 119577.
[25]	乔燕莎, 王茜, 李彦, 等.聚多巴胺涂层聚丙烯疝气补片的制备及其体外炎性反应[J].纺织学报, 2020, 41(9): 162-166.
[26]	Qiao Y, Zhang Q, Wang Q, et al.Synergistic Anti-inflammatory Coating "Zipped Up" on Polypropylene Hernia Mesh[J].ACS Appl Mater Interfaces, 2021, 13(30): 35456-35468.
[27]	Raj R, Shenoy SJ, Mony MP, et al.Surface Modification of Polypropylene Mesh with a Porcine Cholecystic Extracellular Matrix Hydrogel for Mitigating Host Tissue Reaction[J].ACS Appl Bio Mater, 2021, 4(4): 3304-3319.
[28]	Qiao Y, Li Y, Zhang Q, et al.Dopamine-Mediated Zwitterionic Polyelectrolyte-Coated Polypropylene Hernia Mesh with Synergistic Anti-inflammation Effects[J].Langmuir, 2020, 36(19): 5251-5261.
[29]	Muzio G, Perero S, Miola M, et al.Biocompatibility versus peritoneal mesothelial cells of polypropylene prostheses for hernia repair, coated with a thin silica/silver layer[J].J Biomed Mater Res B Appl Biomater, 2017, 105(6): 1586-1593.
[30]	Chou YC, Hsu YH, Lee D, et al.Novel Bioresorbable Drug-Eluting Mesh Scaffold for Therapy of Muscle Injury[J].ACS Biomater Sci Eng, 2024, 10(4): 2595-2606.
[31]	Serrano-Aroca Á, Cano-Vicent A, Tuñón-Molina A, et al.Next generation meshes for hernia repair: Polypropylene meshes coated with antimicrobial benzalkonium chloride induced proliferative activity of fibroblasts[J].Heliyon, 2024, 10(1): e24237.
[32]	Sanbhal N, Saitaer X, Li Y, et al.Controlled Levofloxacin Release and Antibacterial Properties of β-Cyclodextrins-Grafted Polypropylene Mesh Devices for Hernia Repair[J].Polymers(Basel), 2018, 10(5):493.
[33]	Zhu H, Zhou L, Tang J, et al.Reactive Oxygen Species-Responsive Composite Fibers Regulate Oxidative Metabolism through Internal and External Factors to Promote the Recovery of Nerve Function[J].Small, 2024: e2401241.
[34]	Zhao Y, Lang T, Li C, et al.Effect of Electrospinning Network Instead of Polymer Network on the Properties of PDLCs[J].Molecules, 2023, 28(8): 3372.
[35]	Yang D, Song Z, Lin Y, et al.Prevention of intestinal adhesion and regeneration of abdominal wall tissue with meshes containing an electrostatically spun acellular dermal matrix(ADM)/silk fibroin(SF)fiber composite polypropylene mesh[J].J Mech Behav Biomed Mater, 2020, 112: 104087.
[36]	Aydemir Sezer U, Sanko V, Gulmez M, et al.Polypropylene composite hernia mesh with anti-adhesion layer composed of polycaprolactone and oxidized regenerated cellulose[J].Mater Sci Eng C Mater Biol Appl, 2019, 99: 1141-1152.
[37]	Dodda JM， Azar M G， Bělský P， et al.Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lacticco-glycolic acid)[J].Int J Biol Macromol, 2023, 248: 126654.

补片类型	优点	缺点
聚丙烯补片^[4,13-14]	抗张力强、软硬适度、生物惰性、价格便宜	容易引起炎症反应、与腹腔脏器接触可形成粘连、侵蚀肠管
聚丙烯基防粘连复合补片^{[15-17,23-26]}	防止腹腔粘连、排斥反应低、炎症反应轻	收缩和硬化程度高、补片移位可能性大、价格昂贵
聚丙烯基抗菌补片^[29-32]	抗菌能力强、降低补片感染率、生物相容性高	缺乏临床数据、未有理想材料面世
聚丙烯基静电纺丝补片^[29-37]	促进细胞增殖及组织修复、降低炎症反应、防止组织粘连	降解速度快、复发率高、价格昂贵

补片类型	优点	缺点
聚丙烯补片^[4,13-14]	抗张力强、软硬适度、生物惰性、价格便宜	容易引起炎症反应、与腹腔脏器接触可形成粘连、侵蚀肠管
聚丙烯基防粘连复合补片^{[15-17,23-26]}	防止腹腔粘连、排斥反应低、炎症反应轻	收缩和硬化程度高、补片移位可能性大、价格昂贵
聚丙烯基抗菌补片^[29-32]	抗菌能力强、降低补片感染率、生物相容性高	缺乏临床数据、未有理想材料面世
聚丙烯基静电纺丝补片^[29-37]	促进细胞增殖及组织修复、降低炎症反应、防止组织粘连	降解速度快、复发率高、价格昂贵

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