Research progress on the correlation between matrix metalloproteinases and their tissue inhibitors with the occurrence and postoperative recurrence of inguinal hernia

doi:10.3877/cma.j.issn.1674-392X.2025.02.005

Abstract

Abstract:

Inguinal hernia is a superficial mass formed by the protrusion of an intra-abdominal organ through a defect in the inguinal region, and can occur in all age groups.In clinical practice, the incidence of inguinal hernia is relatively high, with a higher prevalence in males than in females.Currently,surgery is the only way to cure inguinal hernia, but with the deeper understanding of the anatomy of the inguinal region and the rapid development of material science, effective and individualized surgical procedures are constantly being improved.Therefore, tension-free hernia repair is widely used in clinical practice, among which the Lichtenstein procedure, with its low-tension suture, fewer complications, and conformity to the human anatomical nodes, has gradually become the mainstream procedure, but some patients still face recurrence.Previous studies have found that matrix metalloproteinases (MMPs) and matrix metalloproteinase inhibitors (TIMPs) can be used as biomarkers related to inguinal hernia development, disease progression, and postoperative prognosis.These factors have some potential clinical value in the pathologic process of the disease by participating in the synthesis, secretion, and inhibition of various proteins in the body.The aim of this review is to provide a narrative on the relevance of MMP and TIMP in the mechanism of inguinal hernia and postoperative recurrence.

Key words: Inguinal hernia, Matrix metalloproteinases, Matrix metalloproteinase inhibitors, Extracellular matrix, Metabolic syndrome

Yakufu Sulayiman, Maimaitiming Maimaitiaili, Aili Aikebaier, Abudureyim Kelim, Arkin Yusanjan, Mukhtar Miralim, Yiliang Li. Research progress on the correlation between matrix metalloproteinases and their tissue inhibitors with the occurrence and postoperative recurrence of inguinal hernia[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(02): 144-149.

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