Application of double-sided asymmetric composite meshes in abdominal wall defect repair

doi:10.3877/cma.j.issn.1674-392X.2024.02.002

Abstract

Abstract:

Tension-free mesh repair is the preferred method for treating abdominal wall defects. However, compared to simple abdominal wall defects such as inguinal hernias, complex abdominal wall defects caused by trauma, abdominal wall stoma, or tumor resection surgeries have become increasingly prevalent in recent years, and higher requirements are placed on the performance of repair materials. Commercial meshes still face many critical challenges in clinical practice, such as infections, intra-abdominal adhesions, slow healing, and mesh displacement, making it difficult to achieve efficient repair of defective tissues. This paper presents an overview of current commercial meshes and novel double-sided asymmetric composite polymer meshes, and provides a perspective on the potential challenges, opportunities, and future research directions in the field of soft tissue repair materials.

Key words: Abdominal wall defect, Mesh, Janus, Composite materials

Yang Ouyang, Yang Yu, Wenxuan Xiong, Hui Wang, Rongkang Huang. Application of double-sided asymmetric composite meshes in abdominal wall defect repair[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(02): 125-131.

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References 63

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分类	结构成分	应用优势	参考文献
天然生物来源材料	胶原蛋白	促血管化、组织修复再生、术后抗粘连	[32]
	几丁质及其衍生物	生物相容性优异、促进创面愈合、透气性良好、药物载体	[30,33]
	明胶	促组织修复、可降解、抗感染、抗黏附	[34]
	纤维素及其衍生物	稳定的溶胀能力、化学惰性、良好的柔韧性及生物相容性、药物载体	[35，36，37]
	多酚类	氧化还原活性、促进腹壁粘合、免疫调节、抗炎症反应、促组织修复	[38，39]
	纤维蛋白	耐受性良好、抗粘连、促进间皮细胞增殖、抑制炎症细胞浸润	[40，41]
合成聚合物来源材料	甲基丙烯酰化明胶	优异的生物相容性、光固化可控反应、促组织修复	[27]
	聚乙烯醇	生物相容性好、溶胀率低、抗变形、抗粘连	[29,42]
	聚乳酸	热稳定、易加工、良好的生物降解性和生物相容性	[43]
	羟基乙酸-乳酸共聚物	良好的生物相容性、易溶解操控成型、可控降解	[44]
	聚己内酯	良好的生物相容性、长效黏附、促细胞生长支架、可降解	[45]
	聚氨酯	易于加工、良好的弹性、生物相容性、药物载体	[46]

分类	结构成分	应用优势	参考文献
天然生物来源材料	胶原蛋白	促血管化、组织修复再生、术后抗粘连	[32]
	几丁质及其衍生物	生物相容性优异、促进创面愈合、透气性良好、药物载体	[30,33]
	明胶	促组织修复、可降解、抗感染、抗黏附	[34]
	纤维素及其衍生物	稳定的溶胀能力、化学惰性、良好的柔韧性及生物相容性、药物载体	[35，36，37]
	多酚类	氧化还原活性、促进腹壁粘合、免疫调节、抗炎症反应、促组织修复	[38，39]
	纤维蛋白	耐受性良好、抗粘连、促进间皮细胞增殖、抑制炎症细胞浸润	[40，41]
合成聚合物来源材料	甲基丙烯酰化明胶	优异的生物相容性、光固化可控反应、促组织修复	[27]
	聚乙烯醇	生物相容性好、溶胀率低、抗变形、抗粘连	[29,42]
	聚乳酸	热稳定、易加工、良好的生物降解性和生物相容性	[43]
	羟基乙酸-乳酸共聚物	良好的生物相容性、易溶解操控成型、可控降解	[44]
	聚己内酯	良好的生物相容性、长效黏附、促细胞生长支架、可降解	[45]
	聚氨酯	易于加工、良好的弹性、生物相容性、药物载体	[46]

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