Abstract:

Objective

To investigate the efficacy and safety of botulinum toxin type A(BTA) in the repair of abdominal wall defects after abdominal opening.

Methods

A retrospective analysis was conducted on the clinical data of 15 patients with abdominal wall defects after open abdominal cavity treated at the Department of General Surgery, Jiangyin People's Hospital, from July 2018 to March 2024.All patients were injected with BTA, and changes in abdominal wall muscle thickness, length, density, defect diameter, and the hernia sac-to-abdominal cavity volume ratio were evaluated 2 weeks after injection.The changes in these parameters before and after treatment were statistically analyzed.

Results

Compared with before injection values, 2 weeks after botulinum toxin injection, the left abdominal wall muscle thickness of 15 patients decreased by (9.93±6.40) mm, and the right abdominal wall muscle thickness decreased by(9.62±4.73) mm.The left abdominal wall muscle length increased by (24.48±21.66) mm, and the right abdominal wall muscle length increased by (18.64±21.60) mm.The abdominal wall defect diameter decreased by (11.91±10.09) mm, the lateral abdominal wall muscle density decreased by (10.67±7.96) HU,and the hernia sac-to-abdominal cavity volume ratio decreased by 3.61% (6.52%).The transverse diameter of the abdominal cavity increased by (9.59±11.60) mm.All differences were statistically significant(P＜0.05).Abdominal injection of BTA did not have a significant effect on the patients' bowel or urinary functions.

Conclusion

BTA is effective and safe for the repair of abdominal wall defects after abdominal opening.

Key words: Abdominal cavity open, Abdominal wall defect, Botulinum toxin, Mechanical tissue structure separation, Chemical tissue structure separation