To observe the effect of Alfentanil combined with Propofol anesthesia in laparoscopic high ligation of the hernia sac in children.

A prospective study of 150 children who planned to receive laparoscopic high ligation of children's hernia sacs in the Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine from July 2017 to June 2022 was conducted. The patients were divided into three groups using a random number table. The Alfentanil group (50 cases) received Alfentanil combined with Propofol anesthesia , the Sufentanil group (n=50) received Sufentanil combined with Propofol anesthesia and the Fentanyl group (n=50) received Fentanyl combined with Propofol anesthesia. Anesthesia effect , heart rate (HR) and blood pressure (MAP) levels at different times of the three groups were compared. Anesthesia time, recovery time, extubation time, dosage of Propofol, cough and perioperative complications of the three groups were recorded. The Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) and the Pediatric Anesthesia Emergence Delirium Scale (PAED) scores during awakening were evaluated.

The overall excellent and good rates of anesthesia in the Alfentanil group, Sufentanil group and Fentanyl group were 100.00%, 98.00% and 98.00%, respectively, and the total incidence of complications in these three groups were 8.00%, 14.00% and 16.00%, respectively, without statistical significance (P>0.05). 1 min after anesthesia maintenance, the levels of heart rate (HR) and mean arterial pressure (MAP) in the three groups were significantly lower than those before anesthesia induction (P<0.05), but there was no statistical significance between the three groups (P>0.05). 30 min after anesthesia maintenance, the levels of HR and MAP in the three groups were significantly lower than those before anesthesia induction, while the levels in the Alfentanil group were higher than those in the Sufentanil group and the Fentanyl group (P<0.05), and there was no statistical significance between the Sufentanil group and the Fentanyl group (P>0.05). Immediately after the operation, the levels of HR and MAP in the three groups were significantly lower than those before anesthesia induction, but there was no statistical significance between the three groups (P>0.05). Anesthesia time, extubation time, recovery time and Propofol dosage in the Alfentanil group were significantly lower than those in the Sufentanil group and the Fentanyl group (P<0.05), but there was no statistical significance between the Sufentanil group and the Fentanyl group (P>0.05). The cough score and cough incidence in the Alfentanil group were significantly lower than those in the Sufentanil group and the Fentanyl group during the induction and awakening period (P<0.05), but there was no statistical significance between the Sufentanil group and the Fentanyl group (P>0.05). The PAED score of the Alfentanil group was significantly lower than that of the Sufentanil group and the Fentanyl group (P<0.05), while the CHEOPS score was slightly lower than that of the Sufentanil group and the Fentanyl group (P>0.05), but there was no statistical significance between the Sufentanil group and the Fentanyl group (P>0.05).

Alfentanil combined with Propofol anesthesia is beneficial to maintain hemodynamic stability and a good quality of recovery during laparoscopic high ligation of the hernia sac in children, effectively reduce the dosage of Propofol during the operation, and reduce the occurrence of complications such as choking and postoperative agitation.