Application of high resolution esophageal manometry (HREM) in the evaluation of esophageal motor function in gastroesophageal reflux disease

doi:10.3877/cma.j.issn.1674-392X.2024.01.017

Abstract

Abstract:

Objective

To analyze the application effect of high resolution esophageal manometry (HREM) in the evaluation of esophageal motor function in gastroesophageal reflux disease (GERD).

Methods

300 patients with GERD (observation group) and 300 normal patients with no reflux symptoms and no abnormal gastroscopy (control group) were selected from the Special Medical Center of the Chinese People's Liberation Army Rocket Force from January 2018 to December 2022. HREM was performed in both groups and the detection results were analyzed.

Results

In terms of internal bolus pressure (IBP), esophageal length, distallatency delay time (DL), and low esophageal sphincter length (LESL), there was no significant difference between the two groups (P>0.05). The contractile front velocity (CFV) in the observation group was significantly higher than that of the control group, while the lower esophageal sphincter pressure (LESP) and distal contractile integral (DCI) were significantly lower than those of the control group (P<0.05). The number of reflux duration ≥5 min, the total pH <4 time, the longest reflux duration, the number of reflux pH <4, the percentage of standing pH <4 time, and the percentage of lying pH <4 time were significantly higher in the observation group than in the control group (P<0.05).

Conclusion

HREM has high application value in the evaluation of esophageal motor function in GERD, and it can accurately reflect the esophageal motor status related to GERD.

Key words: Gastroesophageal reflux disease, Esophageal motor function, high resolution esophageal manometry, Hiatal hernia

Yan Liang, Zhiwei Hu, Jiannan Liu, Qing Song, Dong Chen, Shurui Tian, Ran Li, Jianxin Mao. Application of high resolution esophageal manometry (HREM) in the evaluation of esophageal motor function in gastroesophageal reflux disease[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(01): 89-92.

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URL: https://zhshfbwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-392X.2024.01.017

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References 23

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组别	例数	IBP(mmHg)	食管长度(cm)	DL(s)	LESL(cm)	CFV(cm/s)	LESP(mmHg)	DCI(mmHg·s·cm)	UESP(mmHg)
对照组	300	4.28±3.87	23.68±3.15	5.98±0.87	3.34±0.95	-4.65±2.16	20.76±7.12	1200.15±856.37	66.18±25.16
观察组	300	3.79±2.65	24.03±5.21	5.96±0.93	3.45±1.02	10.13±3.64	12.29±5.51	912.34±123.63	65.89±23.29
t		1.809	0.996	0.272	1.367	60.481	16.295	5.761	0.147
P		0.071	0.319	0.786	0.172	<0.001	<0.001	<0.001	0.884

组别	例数	IBP(mmHg)	食管长度(cm)	DL(s)	LESL(cm)	CFV(cm/s)	LESP(mmHg)	DCI(mmHg·s·cm)	UESP(mmHg)
对照组	300	4.28±3.87	23.68±3.15	5.98±0.87	3.34±0.95	-4.65±2.16	20.76±7.12	1200.15±856.37	66.18±25.16
观察组	300	3.79±2.65	24.03±5.21	5.96±0.93	3.45±1.02	10.13±3.64	12.29±5.51	912.34±123.63	65.89±23.29
t		1.809	0.996	0.272	1.367	60.481	16.295	5.761	0.147
P		0.071	0.319	0.786	0.172	<0.001	<0.001	<0.001	0.884

组别	例数	反流持续≥5 min次数	pH<4总时间(min)	最长反流持续时间(min)	pH<4的反流次数	pH<4的时间百分比
组别	例数	反流持续≥5 min次数	pH<4总时间(min)	最长反流持续时间(min)	pH<4的反流次数	立位	卧位
对照组	300	3.29±2.13	0.57±0.32	0.27±0.15	8.41±2.15	1.13±1.05	0.15±0.10
观察组	300	11.97±3.26	5.31±2.16	2.63±1.12	114.69±23.16	6.23±2.13	4.72±1.28
t		38.607	37.599	36.174	79.143	37.198	61.652
P		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	反流持续≥5 min次数	pH<4总时间(min)	最长反流持续时间(min)	pH<4的反流次数	pH<4的时间百分比
组别	例数	反流持续≥5 min次数	pH<4总时间(min)	最长反流持续时间(min)	pH<4的反流次数	立位	卧位
对照组	300	3.29±2.13	0.57±0.32	0.27±0.15	8.41±2.15	1.13±1.05	0.15±0.10
观察组	300	11.97±3.26	5.31±2.16	2.63±1.12	114.69±23.16	6.23±2.13	4.72±1.28
t		38.607	37.599	36.174	79.143	37.198	61.652
P		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

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