To evaluate the efficacy of biological mesh in laparoscopic trans- abdominal preperitoneal hernia repair (TAPP).

A retrospective analysis was conducted on clinical data of 185 patients who underwent TAPP hernia repair at Liupanshui People's Hospital between January 2018 and December 2023. Based on the type of mesh used during surgery, patients were divided into two groups: 90 cases receiving lightweight large-pole polypropylene mesh were assigned to the control group, while 95 cases receiving biological mesh were assigned to the observation group. Surgical indicators and postoperative complications were recorded; serum inflammatory markers were measured before and after surgery; postoperative pain was assessed; all patients were followed for 6 to 18 months, and post-discharge outcomes were documented.

No statistically significant differences were observed between the two groups in terms of operative time, intraoperative blood loss, or time to ambulation (P>0.05). The total incidence of postoperative complications was significantly lower in the observation group compared to the control group (P=0.025). Three days after surgery, levels of C-reactive protein (CRP) and white blood cell count (WBC) were significantly elevated in both groups compared to preoperative values (P<0.01). Postoperative pain scores were significantly lower in the observation group compared to the control group (P<0.001). No significant difference was found in the incidence of foreign body sensation at the surgical site between the two groups (P>0.05). The incidence of chronic postoperative pain in the surgical area was significantly lower in the observation group (P=0.003), and overall postoperative satisfaction was significantly higher compared to the control group (P<0.001).

The use of biological mesh in TAPP hernia repair in the treatment of adolescent inguinal hernia reduces the risk of postoperative complications and inflammatory responses, alleviates postoperative pain, decreases recurrence rates, and improves prognosis compared to conventional polypropylene mesh.