To investigate the efficacy and safety of domestic biological mesh during laparoscopic transabdominal preperitoneal hernioplasty (TAPP).

Clinical data from 171 patients who underwent TAPP in the Department of General Surgery of Yantai Yuhuangding Hospital between March 2021 and March 2025 were retrospectively analyzed. According to the type of mesh used, the patients were divided into the domestic biological mesh group(adopted BIOSIS HEALING mesh), the imported biological mesh group(adopted COOK mesh), and the polypropylene synthetic mesh group (adopted polypropylene synthetic mesh). Baseline characteristics, operative outcomes, and postoperative complications were compared among the three groups to evaluate the safety and short-term efficacy of the different meshes used in TAPP.

Compared with the polypropylene synthetic mesh group, the biological mesh groups had significantly lower incidences of postoperative pain and local foreign body sensation (P<0.05). However, there were no significant differences in the incidences of postoperative pain or local foreign body sensation between the domestic biological mesh group and the imported biological mesh group (P>0.05). Compared with the polypropylene synthetic mesh group, the biological mesh groups had significantly higher incidences of seroma and fever (P<0.05). However, no significant differences were found in the incidences of seroma or fever between the domestic biological mesh group and the imported biological mesh group (P>0.05). No short-term postoperative complications such as recurrence or mesh infection were observed in any of the three groups.

Domestic BIOSIS HEALING biological mesh is safe and reliable for use in TAPP. Its safety and short-term efficacy are comparable to those of similar imported products. Postoperative seroma and fever are common complications associated with biological mesh, but they are self-limiting and do not lead to adverse outcomes after symptomatic treatment.