Abstract:

Objective

To investigate the pathological changes of abdominal wall muscles after preperitoneal space mesh repair of incision hernia in SD rats.

Methods

Forty-eight SD rats were randomly divided into normal control group （8 rats）， incisional hernia model group （8 rats）， hernia mesh repair group ［1 week postoperative group （8 rats）， 4 weeks postoperative group （8 rats）， 8 weeks postoperative group （8 rats）， 12 weeks postoperative group （8 rats）］. In the control group， rat abdominal wall muscle specimens were taken. In the incision hernia model group， incision hernia modeling was performed， and abdominal wall muscle specimens were taken after 2 weeks. The incision hernia modeling was performed first in the hernia mesh repair group， and mesh repair was performed after successful modeling， and abdominal wall muscle samples were taken 1， 4， 8， 12 weeks after implantation of the mesh，to observe the inflammatory cell infiltration and fibrous tissue proliferation of abdominal wall muscles.

Results

After incision hernia anterior peritoneal space mesh repair， fibrous necrosis， inflammatory cell infiltration， and fibrous tissue hyperplasia occurred in the abdominal wall muscle tissue close to the peritoneum. （1） Degree of inflammatory cell infiltration：compared with the control group， the degree of inflammatory cell infiltration was increased in the incision hernia model group， and the difference was statistically significant （P＜0.05）； compared with the incision hernia model group， the degree of inflammatory cell infiltration was significantly increased in the hernia mesh repair group 1 week after surgery， and the difference was statistically significant （P＜0.05）， while there was no significant difference in the degree of inflammatory cell infiltration in the hernia mesh repair group at 4， 8 and 12 weeks after surgery （P＞0.05）. （2） Degree of fibrous tissue hyperplasia：Compared with the control group， the degree of fibrous tissue hyperplasia was increased in the incision hernia model group and the difference was statistically significant （P＜0.05）； compared with the incision hernia model group， the degree of fibrous tissue hyperplasia was increased in the hernia mesh repair group one week after surgery （P＜0.05）， while there was no significant difference in the hernia mesh repair group 4， 8 and 12 weeks after surgery（P＞0.05）.

Conclusion

After preperitoneal space mesh repair in rats， both surgical trauma and mesh stimulation can lead to muscle fiber necrosis， inflammatory cell infiltration， and fibrous tissue hyperplasia in the abdominal wall muscle tissue close to the peritoneum. This pathological change may be related to the clinical movement pain in the mesh area after preperitoneal space mesh repair.

Key words: Anterior peritoneal space, Mesh, Herniorrhaphy, Abdominal wall muscles, Inflammatory cell infiltration, Fibrous tissue hyperplasia