To investigate the effects of different doses of ropivacaine combined with lidocaine on stress response after inguinal hernia.

A total of 80 patients with tension-free inguinal hernia repair under local anesthesia admitted to Inner Mongolia Baogang Hospital from February to October 2020 were selected and randomly divided into two groups: the compound group and the control group, with 40 cases in each group. The control group was given 0.25% ropivacaine combined with 1% lidocaine for anesthesia, and the compound group was given 0.75% ropivacaine combined with 1% lidocaine for anesthesia. Stress response indexes [cortisol, interleukin6 (IL-6)], Ramsay sedation score, visual analogue scale (VAS) score, postoperative recovery, and incidence of intraoperative adverse events were compared between 2 groups at each time.

The VAS score at 2 hours and 4 hours after surgery was gradually decreased in both groups, and the VAS score of the compound group was lower than the control group at each time point after surgery, and the difference was statistically significant (P<0.05). The comparison of stress response indexes between the two groups showed that the levels of serum cortisol and IL-6 in T1 groups were higher than those in T0 stage, but lower in the compound group than in the control group (P<0.05); the levels of serum cortisol and IL-6 in T2 groups were lower than those in T1 stage, but lower in the compound group than in the control group, with statistical significance (P<0.05). The Ramsay sedation score was significantly decreased compared with the control group, and the difference was statistically significant (P<0.05). The recovery time of patients in the compound group was shorter than that in the control group (P<0.05). The incidence of intraoperative adverse reactions in compound group (1/40) was significantly lower than that in control group (7/40), and the difference was statistically significant (P<0.05).

The combination of 0.75% ropivacaine with 1% lidocaine has a significant analgesic effect in patients after inguinal hernia surgery, which can reduce inflammation, has few adverse reactions, and has clinical promotion significance.