Anesthesia effect of dexmedetomidine combination with midazolam nasal drip before operation in children with indirect hernia

doi:10.3877/cma.j.issn.1674-392X.2019.03.010

Abstract

Abstract:

Objective

To explore the anesthetic effect of dexmedetomidine combination with midazolam nasal drip in pediatric indirect hernia surgery.

Methods

156 children with indirect hernia treated in the general surgery in Honghu People's hospital from January 2016 to November 2018 were randomly divided into the dexmedetomidine group (78 cases) and the combination group (78 cases). All the children were given dexmedetomidine nasal drops 30 minutes before operation, while those in the combination group were added with midazolam. The vital signs, sleeping time, awakening time, the score of sedation effect, the score of CHEOPS, face mask acceptance rate, restlessness rate and sedation satisfaction were observed and compared between the two groups.

Results

There was no significant difference in the levels of heart rate (HR), pulse oxygen saturation (SpO₂) and breathing rate (BR) between the two groups at 10 minutes after nasal drip and 30 minutes after nasal drip compared with before nasal drip, and 30 minutes after nasal drip compared with 10 minutes after nasal drip (P>0.05). The sleeping time in the combination group was shorter than that in the dexmedetomidine group (P<0.05), but there was no significant difference in the awakening time between the two groups (P>0.05). The score of Ramsay sedation in the combination group was higher than that in the dexmedetomidine group and the score of CHEOPS was lower than that in the dexmedetomidine group (P<0.05). The face mask acceptance rate in the combination group was 92.307%, higher than 67.949% of the dexmedetomidine group; the sedation satisfaction rate was 92.307%, higher than 71.795% of the dexmedetomidine group; the agitation rate in the combination group was 5.128%, lower than 25.641% of the dexmedetomidine group. There were significant differences in the three indicators between the two groups (P<0.05).

Conclusion

Dexmedetomidine combination with midazolam nasal drip before operation in pediatric indirect hernia surgery has good anesthetic effect, quick onset, can significantly shorten the sleeping time of children, produce good sedative and analgesic effects, and is worthy of clinical promotion and application.

Key words: Dexmedetomidine, Midazolam, Nasal drip, Pediatric indirect hernia, Vital signs, the score of CHEOPS

Wei Wei, Qiao Fang, Wei Li, Song Tian. Anesthesia effect of dexmedetomidine combination with midazolam nasal drip before operation in children with indirect hernia[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2019, 13(03): 231-234.

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References 21

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组别	时间	心率(次/min)	血氧饱和度(%)	呼吸频率(次/min)
联合组	滴鼻后10 min	123.51±11.58	99.11±8.94	27.15±5.26
右美托咪定组		125.19±12.07	99.12±8.73	26.81±5.28
t值		0.887	0.007	0.403
P值		0.376	0.994	0.388
联合组	滴鼻后30 min	115.28±9.19^a	98.72±8.71^a	23.58±4.15^a
右美托咪定组		114.17±8.93^a	98.64±8.69^a	24.16±4.18^a
t值		0.765	0.057	0.870
P值		0.445	0.954	0.386

组别	时间	心率(次/min)	血氧饱和度(%)	呼吸频率(次/min)
联合组	滴鼻后10 min	123.51±11.58	99.11±8.94	27.15±5.26
右美托咪定组		125.19±12.07	99.12±8.73	26.81±5.28
t值		0.887	0.007	0.403
P值		0.376	0.994	0.388
联合组	滴鼻后30 min	115.28±9.19^a	98.72±8.71^a	23.58±4.15^a
右美托咪定组		114.17±8.93^a	98.64±8.69^a	24.16±4.18^a
t值		0.765	0.057	0.870
P值		0.445	0.954	0.386

组别	面罩接受	发生躁动	镇静满意
联合组	72(92.31)	4(5.13)	72(92.31)
右美托咪定组	53(67.95)	20(25.64)	56(71.80)
χ²值	14.533	12.606	11.143
P值	<0.001	<0.001	0.001

组别	面罩接受	发生躁动	镇静满意
联合组	72(92.31)	4(5.13)	72(92.31)
右美托咪定组	53(67.95)	20(25.64)	56(71.80)
χ²值	14.533	12.606	11.143
P值	<0.001	<0.001	0.001

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