Study on effect chamber concentration of remifentanil inhibiting the body motion response of children undergoing hernia repair under general anesthesia

doi:10.3877/cma.j.issn.1674-392X.2019.01.014

Abstract

Abstract:

Objective

To investigate the effective concentration of remifentanil inhibiting the body movement in children undergoing hernia repair with no muscle relaxation.

Methods

From January 2017 to February 2018, twenty-eight children (age<12 years old) underwent selective hernia repair and ASA grade I or II in the 82nd Group Military Hospital of PLA were enrolled. Anesthesia induction and maintenance were performed with propofol (Marsh model) and remifentanil (Minto model). BIS was controlled ranging from 45 to 55. The initial effect chamber concentration of remifentanil was 4.0 ng/ml and the next patient's target effect chamber concentration of remifentanil was adjusted according to the positive reaction (no body motion response) in the former child and Dixon up-and-down method, with an adjustment range of 0.2 ng/ml. After seven negative-positive reaction crossovers, the EC50 and EC95 (effective concentration) were calculated based on the mean of the negative-positive reaction pair and Probit regression.

Results

The EC50 of remifentanil in the inhibition of body movement in children undergoing hernia repair was 3.99 ng/ml. The EC50 and EC95 were 3.90 ng/ml and 4.34 ng/ml, respectively, by Probit regression analysis.

Conclusion

The EC50 and EC95 of the effect chambers inhibiting the body motion of children undergoing hernia repair were 3.90 ng/ml and 4.34 ng/ml.

Key words: Hernia repair, Remifentanil, Children, Body motion

Sanjun Zhao, Hongqiang Zhang, Jianrui Xiao, Dongdong Lu, Qingchun Cheng. Study on effect chamber concentration of remifentanil inhibiting the body motion response of children undergoing hernia repair under general anesthesia[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2019, 13(01): 51-53.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhshfbwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-392X.2019.01.014

https://zhshfbwkzz.cma-cmc.com.cn/EN/Y2019/V13/I01/51

Figures/Tables 2

References 12

[1]	Tulgar S, Boga I, Cakiroglu B, et al. Short-lasting pediatric laparoscopic surgery: Are muscle relaxants necessary? Endotracheal intubation vs. laryngeal mask airway[J]. J Pediatr Surg, 2017, 52(11): 1705-1710.
[2]	Ahiskalioglu A, Ince I, Ahiskalioglu E O, et al. Is Neuromuscular Blocker Necessary in Pediatric Patients Undergoing Laparoscopic Inguinal Hernia Repair with Percutaneous Internal Ring Suturing?[J]. Eur J Pediatr Surg, 2017, 27(3): 263-268.
[3]	Kim M K, Lee J W, Jang D J, et al. Effect-site concentration of remifentanil for laryngeal mask airway insertion during target- controlled infusion of propofol[J]. Anaesthesia, 2009, 64(2): 136-140.
[4]	Dixon WJ. Staircase bioassay: the up-and-down method[J]. Neurosci Biobehav Rev, 1991, 15(1): 47-50.
[5]	Campanelli G, Bruni PG, Morlacchi A, et al. Primary inguinal hernia: The open repair today pros and cons[J]. Asian J Endosc Surg, 2017, 10(3): 236-243.
[6]	Soderstrom CM, Borregaard Medici R, Assadzadeh S, et al. Deep neuromuscular blockade and surgical conditions during laparoscopic ventral hernia repair: A randomised, blinded study[J]. Eur J Anaesthesiol, 2018, 35(11): 876-882.
[7]	Kamata M, Tobias JD. Remifentanil: applications in neonates[J]. J Anesth, 2016, 30(3): 449-460.
[8]	Fuentes R, Cortinez LI, Contreras V, et al. Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children[J]. Paediatr Anaesth, 2018, 28(12): 1078-1086.
[9]	Palumbo P, Usai S, Amatucci C, et al. Inguinal hernia repair in day surgery: the role of MAC(Monitored Anesthesia Care) with remifentanil[J]. G Chir, 2017, 38(6): 273-279.
[10]	Chen BZ, Chu QJ, Yu J R, et al. The effect of remifentanil on the minimum alveolar concentration of isoflurane in children[J]. J Clin Anesth, 2015, 27(6): 504-507.
[11]	Choi SC. Interval estimation of the LD50 based on an up-and-down experiment[J]. Biometrics, 1990, 46(2): 485-492.
[12]	Han JU, Cho S, Jeon WJ, et al. The optimal effect-site concentration of remifentanil for lightwand tracheal intubation during propofol induction without muscle relaxation[J]. J Clin Anesth, 2011, 23(5): 379-383.

[1]	Hongyu Tao, Jingjing Ye, Jin Yu, Xiuzhen Yang, Jingjing Qian, Bin Xu, Weize Xu, Qiang Shu. Value of contrast transthoracic echocardiography in assessing right-to-left shunt-related diseases in children [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(10): 959-965.
[2]	Xiaoli Yang, Wanfu Li, Zhu Ma, Lan Ma, Yi Zheng, Xiaoli Fu, Jing Wang. Application effect of one-step forceps needle method in laparoscopic high ligation of hernia sac in children [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 535-538.
[3]	Dongyang Ma, Bin Li, Anqing Lu, Guanghua Wang, Wenzhang Lei, Yinghan Song. Randomized controlled trial on the curative effect of the Gilbert procedure and single mesh preperitoneal hernia repair [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 629-633.
[4]	Haoyuan Wang, Haiyang Wang, Jianming Sun, Yikuan Chen, Xiaotong Qi, Bo Tang. Comparison of laparoscopic and open surgery on early postoperative liver function and coagulation function in patients with abdominal external hernia and cirrhosis [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 654-659.
[5]	Zhengyang Zhou, Kai Chen, Duoliang Qiu, Lening Shao, Haorong Wu, Fengyun Zhong. Analysis and management of postoperative hemorrhage following laparoscopic inguinal hernia repair [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 660-664.
[6]	Xi Gu, Ziyu Xu, Shu Zhou, Wulou Zhang, Yepeng Zhang, Hao Lin, Zonghang Liu, Zhengling Ji, Lifeng Zheng. Mesh infection after tension-free preperitoneal inguinal hernia repair: A report of 10 cases [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 665-669.
[7]	Jialin Zhu, Xiang Fang, Shiyu Gui, Dan Huang, Xiaoyu Zhou, Wenkai Guo. Expression of VEGF and Ang-1 in serum after incisional hernia preperitoneal gap patch repair in rats [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 703-707.
[8]	Yuanyuan Yang, Xianchao Lin, Ronggui Lin, Fengchun Lu, Heguang Huang. Prevention and treatment of postoperative complications in repairing giant incisional hernia with muscle posterior/preperitoneal mesh [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 645-648.
[9]	Zhijing Yuan, Jie Huang, Guoan He, Huiqiang Fang. Application of local block anesthesia with ropivacaine and dexmedetomidine in elderly patients undergoing laparoscopic tension-free inguinal hernia repair [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 557-561.
[10]	Hebei Ding, Xun Wang, Weiguo Chen. Comparison of application of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in pediatric indirect inguinal hernia surgery [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 570-574.
[11]	Qi Han, Maimaitiming Maimaitiaili, Xudong Huang, Hao Wang, Abudureyimu Kelimu, Aili Aikebaier. Mid-term efficacy analysis of laparoscopic sleeve gastrectomy or combined with hiatal hernia repair in the treatment of obesity with gastroesophageal reflux disease [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 501-506.
[12]	Chinese Society of Organ Transplantation of Chinese Medical Association, Surgery Group of Chinese Society of Surgery of Chinese Medical Association, Transplantation Group of Chinese Society of Surgery of Chinese Medical Association, South China Alliance of Split Liver Transplantation. Chinese Clinical Practice Guidelines on Split Liver Transplantation in Children [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 593-601.
[13]	Chen Zhang, Ming Qin, Juan Dong, Yulong Chen. Diagnostic value of ultrasound in ischemic changes of intestinal volvulus in children [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 565-568.
[14]	Xiaosheng Chen, Jia He, Fang Liu, Rui Wu, Haitao Yang, Xiaohan Fan. Pacemaker implantation in a child with a 31-second cardiac arrest induced by tilt table test: a case report and literature review [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 488-494.
[15]	Yali Cao, Yumeng Gao, Yingqian Zhang, Bo Li, Junbao Du, Hongfang Jin. Clinical progress of sitting intolerance in children [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 510-515.

Please choose a citation manager

Content to export