Objective To investigate the effect of preoperative etoricoxib on postoperative pain control in patients with open inguinal hernia repair.
Methods From January 2016 to September 2018, clinical data of 60 elderly patients undergoing open inguinal hernia repair in the Sixth People's Hospital of Huizhou were selected and a single-center, randomized, double-blind, placebo-controlled trial were performed. Thirty patients in the test group received 120 mg of oral etoricoxib 1 h before surgery; 30 patients in the control group received oral placebo 1 h before surgery and used bupivacaine for lumbar spinal anesthesia. Record and analyze postoperative visual analog score at rest. Record whether the patient required supplemental analgesia, the number of analgesics given, the total dose, and the postoperative adverse reactions within 24 hours.
Results The visual analogue scores of pain in the experimental group at 4, 8, 12, 16, and 24 hours were (2.47±1.33) scores, (2.50±1.74) scores, (2.63±1.22) scores, (3.37±0.67) scores, and (2.67±1.14) scores, respectively. The visual analogue scores for pain at 8, 12, 16, and 24 hours were (3.03±1.30) scores, (3.70±1.86) scores, (4.27±1.68) scores, (3.83±1.70) scores, and (2.93±1.11) scores. The test groups were significantly lower than the control group, and the differences were statistically significant (P<0.05). Patients in the test group needed supplemental analgesia for (178.20±41.45) minutes, which was significantly higher than that in the control group (142.80±61.75) minutes. The number of analgesic dose supplements and doses in the experimental group within 24 hours were (2.67±0.96) times, (7.40±4.28) mg, which was significantly lower than (3.43±1.48) times and (11.20±6.17) mg of the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse events between the two groups (P>0.05).
Conclusion Etoricoxib combined with lumbar spinal anesthesia can improve the pain of elderly patients with open inguinal hernia repair.