Postoperative analgesic effect of etoricoxib in combination with spinal anesthesia in open inguinal hernia repair

doi:10.3877/cma.j.issn.1674-392X.2020.01.009

Abstract

Abstract:

Objective

To investigate the effect of preoperative etoricoxib on postoperative pain control in patients with open inguinal hernia repair.

Methods

From January 2016 to September 2018, clinical data of 60 elderly patients undergoing open inguinal hernia repair in the Sixth People's Hospital of Huizhou were selected and a single-center, randomized, double-blind, placebo-controlled trial were performed. Thirty patients in the test group received 120 mg of oral etoricoxib 1 h before surgery; 30 patients in the control group received oral placebo 1 h before surgery and used bupivacaine for lumbar spinal anesthesia. Record and analyze postoperative visual analog score at rest. Record whether the patient required supplemental analgesia, the number of analgesics given, the total dose, and the postoperative adverse reactions within 24 hours.

Results

The visual analogue scores of pain in the experimental group at 4, 8, 12, 16, and 24 hours were (2.47±1.33) scores, (2.50±1.74) scores, (2.63±1.22) scores, (3.37±0.67) scores, and (2.67±1.14) scores, respectively. The visual analogue scores for pain at 8, 12, 16, and 24 hours were (3.03±1.30) scores, (3.70±1.86) scores, (4.27±1.68) scores, (3.83±1.70) scores, and (2.93±1.11) scores. The test groups were significantly lower than the control group, and the differences were statistically significant (P<0.05). Patients in the test group needed supplemental analgesia for (178.20±41.45) minutes, which was significantly higher than that in the control group (142.80±61.75) minutes. The number of analgesic dose supplements and doses in the experimental group within 24 hours were (2.67±0.96) times, (7.40±4.28) mg, which was significantly lower than (3.43±1.48) times and (11.20±6.17) mg of the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse events between the two groups (P>0.05).

Conclusion

Etoricoxib combined with lumbar spinal anesthesia can improve the pain of elderly patients with open inguinal hernia repair.

Key words: Hernia, inguinal, Etoricoxib, Postoperative analgesia

Jianbo Cai, Changjiang Chen, Lijing Luo. Postoperative analgesic effect of etoricoxib in combination with spinal anesthesia in open inguinal hernia repair[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2020, 14(01): 34-38.

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References 31

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组别	例数	年龄(岁,±s)	体重(kg,±s)	体质量指数(kg/m²,±s)	美国麻醉师协会分级(Ⅱ/Ⅲ级)[例(%)]	手术时间(min,±s)	麻醉持续时间(min,±s)
对照组	30	67.83±4.89	70.97±4.62	22.65±3.08	23(76.67)	54.12±15.88	133.62±16.41
试验组	30	66.73±3.82	69.53±3.98	21.60±2.66	25(83.33)	49.10±13.87	128.30±17.78
检验值		t=0.970	t=1.285	t=1.413	χ²=0.417	t=1.299	t=1.200
P值		0.336	0.204	0.163	0.748	0.199	0.235

组别	例数	年龄(岁,±s)	体重(kg,±s)	体质量指数(kg/m²,±s)	美国麻醉师协会分级(Ⅱ/Ⅲ级)[例(%)]	手术时间(min,±s)	麻醉持续时间(min,±s)
对照组	30	67.83±4.89	70.97±4.62	22.65±3.08	23(76.67)	54.12±15.88	133.62±16.41
试验组	30	66.73±3.82	69.53±3.98	21.60±2.66	25(83.33)	49.10±13.87	128.30±17.78
检验值		t=0.970	t=1.285	t=1.413	χ²=0.417	t=1.299	t=1.200
P值		0.336	0.204	0.163	0.748	0.199	0.235

组别	例数	术后4 h	术后8 h	术后12 h	术后16 h	术后24 h
试验组	30	2.47±1.33	2.50±1.74	2.63±1.22	3.37±0.67	2.67±1.14
对照组	30	3.03±1.30	3.70±1.86	4.27±1.68	3.83±1.70	2.93±1.11
F值		F_组间=34.130，F_时间=8.875，F_交互=5.234
P值		P_组间<0.001，P_时间<0.001，P_交互=0.001

组别	例数	术后4 h	术后8 h	术后12 h	术后16 h	术后24 h
试验组	30	2.47±1.33	2.50±1.74	2.63±1.22	3.37±0.67	2.67±1.14
对照组	30	3.03±1.30	3.70±1.86	4.27±1.68	3.83±1.70	2.93±1.11
F值		F_组间=34.130，F_时间=8.875，F_交互=5.234
P值		P_组间<0.001，P_时间<0.001，P_交互=0.001

变量	例数	第1次按需镇痛的时间(min)	术后24 h内镇痛剂量补充次数(次)	术后24 h内吗啡的镇痛剂量(mg)
对照组	30	142.80±61.75	3.43±1.48	11.20±6.17
试验组	30	178.20±41.45	2.67±0.96	7.40±4.28
t值		-2.607	2.380	2.769
P值		0.012	0.020	0.008

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