To evaluate the clinical efficacy of negative-pressure ostomy techniques in managing enteroatmospheric fistula and stoma mucocutaneous separation.

A retrospective case series study was conducted on clinical data of 11 patients with enteroatmospheric fistula and stoma mucocutaneous separation treated with negative-pressure ostomy techniques in the Department of General Surgery, Jiangyin people's Hospital from August 2022 to August 2024. Primary outcomes included digestive fluid management and wound contamination, while secondary observation indicators included wound healing status, inflammatory markers, and albumin levels.

The study included 11 patients, 6 males and 5 females, with a mean age of (62.3±12.5) years. Among them, 3 cases had enteroatmospheric fistulas, and 8 cases had stoma mucocutaneous separations. All patients underwent negative-pressure ostomy therapy for a mean duration of (26.1±10.7) days. After the treatment, all wound infections were effectively controlled, with healthy granulation tissue formation. Inflammatory markers (white blood cells, C-reactive protein) significantly decreased compared to those before treatment (P<0.05). No complications such as wound bleeding, new-onset digestive tract fistula, or foreign body retention were observed. The mean follow-up duration was (24±6.5) months. By the last follow-up on August 20, 2025, no cases of digestive tract stenosis, fistula recurrence, or abscess formation were detected.

Negative- pressure ostomy techniques can effectively manage leakage fluid, reduce peristomal wound contamination and infection, and promote granulation tissue regeneration.