Abdominal wall tumor–related diseases include both primary and metastatic lesions. Their diagnosis and treatment require the formulation of individualized therapeutic strategies based on the tumor’s biological behavior while simultaneously addressing the reconstruction of abdominal wall defects caused by surgical resection. Within this complex clinical context, a multi-disciplinary team model plays a pivotal role in therapeutic decision-making, facilitating the dual goals of tumor control and functional restoration. In recent years, the development of novel reconstructive materials—such as composite meshes and drug-loaded meshes—has diversified abdominal wall reconstruction techniques, offering new technological approaches to reduce postoperative recurrence, improve tissue healing quality, and enhance reconstruction success rates. These advances hold promise for achieving superior overall treatment outcomes in patients with abdominal wall diseases related to tumors.