To explore the effect of low-dose sevoflurane and oxycodone on anesthesia in laparoscopic inguinal hernia repair.

A total of 94 patients undergoing elective laparoscopic inguinal hernia repair in Shanxi Jincheng University Hospital from February 2020 to December 2021 were selected as the subjects, and all patients were divided into control group (47 cases) and observation group (47 cases) according to different anesthesia methods. Low-dose sevoflurane inhalation was maintained in both groups. Oxycodone hydrochloride was injected intravenously 30 min before the end of surgery in the observation group. The control group was given sufentanil. The awaking time (from anesthesia to self-opening) and waking time (self-pointing nose) of patients in the two groups were analyzed. Visual analogue scale (VAS) was used to evaluate the pain degree of patients in the two groups at 1, 6, and 24 h after surgery. Stress indexes such as mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO₂) after induction (T₁) and extubation (T₂) were recorded. Inflammatory factors such as hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor -α (TNF-α) before anesthesia and on the first day after surgery, and the incidence of postoperative adverse reactions were also recorded.

The awaking time and waking time in the observation group were less than those in the control group (P<0.05). Patients in the observation group had significantly lower VAS scores at 1, 6, and 24 h than the control group (P<0.05). Compared with T₁, MAP and HR increased in T₂, and the SpO₂ decreased in both groups. The MAP and HR fluctuations in T₁ and T₂ were lower in the observation group than those in the control group, and SpO₂ was higher than that in the control group (P<0.05). Compared with before anesthesia, the inflammatory factors were significantly increased in the first postoperative day in both groups (P<0.05), and the inflammatory factor index in the observation group was lower than that in the control group (P<0.05). The total adverse reaction rate in the observation group (12.77%) was lower than that in the control group (29.79%), the difference was statistically significant (P<0.05).

Low-dose sevoflurane combined with oxycodone can help maintain hemodynamic stability in patients undergoing laparoscopic inguinal hernia repairs, effectively relieve postoperative pain and systemic inflammation, and reduce stress reactions and adverse reactions.