Effect of dexmedetomidine combined with ropivacaine on nerve block in elderly patients undergoing laparoscopic inguinal hernia repair

doi:10.3877/cma.j.issn.1674-392X.2022.03.008

Abstract

Abstract:

Objective

To analyze the effect of dexmedetomidine combined with ropivacaine on nerve block in elderly patients undergoing laparoscopic inguinal hernia repair.

Methods

66 elderly patients with inguinal hernia admitted in general surgery of Ningguo city people's hospital from December 2019 to December 2020 were selected as the research subjects. The patients were divided into two groups using the random number table method: control group (33 cases) was given ropivacaine, observation group (33 cases) was given dexmedetomidine combined with ropivacaine. The heart rate (HR), mean arterial pressure (MAP) of patients in the two groups were analyzed, the stress response indicators of patients in the two groups were detected, the onset time of sensory block and analgesia duration of patients in the two groups were compared, the visual analog score (VAS) score and Ramsay score of patients in the two groups were evaluated, and the incidence of complications of patients in the two groups were analyzed.

Results

After operation, HR level in the observation group were significantly lower than that in the control group, and MAP level was significantly higher than that in the control group (P<0.05). The levels of IL-6, Cor and Glu in the observation group were significantly lower than those in the control group (P<0.05). The duration of analgesia in the observation group was significantly longer than that in the control group, and the onset time of sensory block was significantly shorter than that in the control group (P<0.05). At 2 h and 6h after surgery, Ramsay score in the observation group was significantly higher than that in the control group, and VAS score was significantly lower than that in the control group (P<0.05). The complication rate in the observation group was 15.15%, which was slightly lower than 18.18% in the control group (P>0.05).

Conclusion

Dexmedetomidine combined with ropivacaine can effectively maintain the hemodynamic stability of elderly patients undergoing laparoscopic inguinal hernia repair, reduce their stress response, accelerate the onset time of anesthesia.

Key words: Dexmedetomidine, Ropivacaine, Laparoscopes, Hernia, inguinal

Huiqiang Fang, Jie Huang, Guoan He, Yun Luo, Yanfei He. Effect of dexmedetomidine combined with ropivacaine on nerve block in elderly patients undergoing laparoscopic inguinal hernia repair[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2022, 16(03): 282-285.

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References 19

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组别	例数	心率(次/min)		平均动脉压(mmHg)
组别	例数	麻醉前	术毕	麻醉前	术毕
观察组	33	67.45±3.51	73.30±2.23^*	105.48±7.44	99.21±3.37^*
对照组	33	67.33±3.31	75.27±2.11^*	106.73±7.36	96.36±3.27^*
t值		0.14	3.69	0.69	3.49
P值		0.89	<0.001	0.50	<0.001

组别	例数	心率(次/min)		平均动脉压(mmHg)
组别	例数	麻醉前	术毕	麻醉前	术毕
观察组	33	67.45±3.51	73.30±2.23^*	105.48±7.44	99.21±3.37^*
对照组	33	67.33±3.31	75.27±2.11^*	106.73±7.36	96.36±3.27^*
t值		0.14	3.69	0.69	3.49
P值		0.89	<0.001	0.50	<0.001

组别	例数	白介素6(pg/ml)		皮质醇(nmol/L)		血糖(mmol/L)
组别	例数	麻醉前	术毕	麻醉前	术毕	麻醉前	术毕
观察组	33	52.21±3.47	56.88±3.16^*	305.52±30.55	319.21±23.46^*	4.73±0.45	5.33±0.48^*
对照组	33	52.30±3.31	59.48±3.02^*	303.85±32.37	334.76±24.20^*	4.70±0.47	5.76±0.44^*
t值		0.11	3.42	0.22	2.65	0.26	3.79
P值		0.91	<0.001	0.83	0.01	0.79	<0.001

组别	例数	白介素6(pg/ml)		皮质醇(nmol/L)		血糖(mmol/L)
组别	例数	麻醉前	术毕	麻醉前	术毕	麻醉前	术毕
观察组	33	52.21±3.47	56.88±3.16^*	305.52±30.55	319.21±23.46^*	4.73±0.45	5.33±0.48^*
对照组	33	52.30±3.31	59.48±3.02^*	303.85±32.37	334.76±24.20^*	4.70±0.47	5.76±0.44^*
t值		0.11	3.42	0.22	2.65	0.26	3.79
P值		0.91	<0.001	0.83	0.01	0.79	<0.001

组别	例数	感觉阻滞起效时间	镇痛持续时间
观察组	33	10.84±1.00	803.07±108.67
对照组	33	11.86±1.22	739.10±128.35
t值		3.71	2.19
P值		<0.001	0.03

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