The seroma is a common complication after laparoscopic inguinal hernia repair. There is no consistent opinion on how to prevent the occurrence of seroma after laparoscopic hernia surgery. This article describes the mechanism, risk factors and preventive management of postoperative seroma following laparoscopic hernia repair, and introduces our clinical experience in this field. The incidence of seroma in the direct inguinal hernia and the large indirect or scrotal hernia is high. For the direct inguinal hernias, it is recommended to close the hernia sac during laparoscopic hernia repair (with barbed suture or endoloop). For large indirect inguinal hernias, it can be performed with distal sac hung with a barbed suture. For some special cases, it can selectively place the drainage tube and pull out the drainage at an early stage.