To explore the effects of oxycodone combined with sufentanil in patients undergoing laparoscopic hernia repair.

The clinical data of 80 patients with inguinal hernia admitted to Deyu Medical Ma'anshan General Hospital from July 2021 to July 2022 were retrospectively analyzed, and patients were divided into 2 groups according to different anesthesia methods, with 40 patients in each group. The control group was anesthetized with oxycodone combined with propofol+ cis-atracurium, and the experimental group was anesthetized with sufentanil on the basis of the control group. Intraoperative conditions, visual analogue scores (VAS) of anesthesia effects, hemodynamics, pain mediators, adverse reactions were analyzed between the 2 groups.

The operation and anesthesia time of patients in the 2 groups was not statistically significant (P>0.05). The awakening time of the experimental group was less than that of the control group, and the difference was statistically significant [(9.72±4.49) min vs (26.33±6.11) min, P<0.05]. There was no statistically significant difference in the disappearing time of the call to open the eyes of the patients between the 2 groups (P>0.05); The onset time of anesthesia in the control group was shorter than that in the experimental group, the disappearance time of swallowing reflex was longer than that in the experimental group, and the VAS score was higher than that of the control group patients, and the difference was statistically significant [(8.98±1.86) min vs (9.74±2.66) min, (4.98±0.59) min vs (2.79±0.89) min, (3.33±1.56) points vs (2.42±1.49) points; P<0.05]. At 8, 12, and 24 h after surgery, the mean arterial pressure, heart rate, and respiratory rate of patients in the experimental group were lower than those in the control group, and the difference was statistically significant (P<0.05); There was no significant difference in the SpO₂ levels of patients between the 2 groups (P>0.05). Before operation, the expression levels of prostaglandin E2, 5-hydroxytryptamine and substance P in the 2 groups of patients were not statistically significant (P>0.05); After operation, the expression levels of prostaglandin E2, 5-hydroxytryptamine and substance P between the 2 groups of patients were elevated, but the expression levels in the experimental group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions such as drowsiness, hypotension, respiratory depression, and choking in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05).

Oxycodone combined with sufentanil anesthesia in patients undergoing laparoscopic hernia repair effectively improves patients' pain scores with less impact on body hemodynamics and pain mediators.