To investigate the effects of nabuprorphine combined with propofol on anesthetic effect, stress response and inflammatory factors in laparoscopic inguinal hernia repair.

From January 2020 to June 2022, 80 patients who underwent laparoscopic transabdominal preperitoneal inguinal hernia repair (TAPP) in Ma 'anshan People's Hospital of Anhui Province were selected as the research objects. According to the random number table method, they were divided into the control group and the observation group, with 40 cases in each group. Both groups were given general anesthesia by tracheal intubation. During anesthesia induction, the control group was combined with sufentanil, and the observation group was combined with nalbuphine. The mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SPO₂) before operation, during skin incision and recovery were compared between the two groups. The analgesic effect (visual analogue scale) at 0.5 h, 2 h, 6 h and 12 h after operation, and the adverse reactions induced by anesthetics were compared between the two groups. The serum stress response indices [epinephrine, norepinephrine (NE), cortisol] and serum inflammatory response indices [interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α)] were measured 0.5 h before and 4 h after the operation.

There were no significant differences in mean arterial pressure, heart rate, or blood oxygen saturation between the two groups before surgery, during the skin incision, and when awake (P>0.05). The VAS scores of the observation group were lower than those of the control group at 2, 6, 12 h after the operation (P<0.05), 0.5 h after operation, there was no significant difference between the two groups (P>0.05). There was no significant difference in the adverse reactions induced by anesthetic drugs between the two groups (P>0.05). There was no significant difference in epinephrine, NE, cortisol, IL-6, CRP and TNF-α between the two groups 0.5 h before operation (P>0.05). At 4 hours after the operation, both groups were increased, and the observation group was lower than the control group (P<0.05).

Under general anesthesia with endotracheal intubation, the application of nalbuphine in TAPP surgery can achieve a good anesthetic effect, reduce the degree of postoperative pain, inhibit the intensity of the stress response and inflammatory response, and does not increase the risk of adverse drug reactions.