To investigate the efficacy of complete stripping of the hernia sac and transection of hernia sac in laparoscopic transabdominal preperitoneal repair (TAPP) for unilateral indirect inguinal hernia.

From March 2020 to March 2021, 85 patients with indirect inguinal hernia who underwent TAPP in Jiangning Hospital Affiliated with Nanjing Medical University were selected as the research subjects. According to the odd and even numbers of admissions, they were divided into a transection group (43 cases) and a dissection group (42 cases). The general surgical conditions, pain indexes, oxidative stress indexes such as growth hormone (GH), insulin (InS), blood sugar (BS) and total antioxidant capacity (T-AOC), serum immune indexes and postoperative complications were compared between the two groups.

The operation time, inguinal effusion, intraoperative blood loss and hospitalization time in the transection group were significantly better than those in the dissection group (P<0.05); The degree of pain in the transection group 1 d, 3 d and 1 week after the operation was significantly lower than that in the dissection group (P<0.05); The levels of GH, InS and T-AOC in the transection group were significantly higher than those in the dissection group (P<0.05), and the level of BS was significantly lower than that in the dissection group (P<0.05); Serum levels of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and TIMP-2 in the two groups significantly decreased compared with those before the operation (P<0.05), and there was no significant difference in serum levels between the two groups after the surgery (P>0.05); There were no significant differences in postoperative seroma, neuroparesthesia and urinary retention between 2 groups (P>0.05).

Both complete dissection and transection of the hernia sac have good efficacy in the treatment of unilateral inguinal hernia, but transection of the hernia sac plays a more positive role in reducing the operation time, alleviating the pain of patients, alleviating the stress response, and expediting the recovery of patients.