To investigate the effects of ropivacaine local infiltration anesthesia combined with general anesthesia on stress reaction and clinical indicator of patients undergoing laparoscopic total extraperitoneal hernia repair (TEP).

98 cases who were admitted to Tianchang Hospital of Traditional Chinese Medicine from December 2017 to January 2019 and undergoing laparoscopic TEP surgery were selected as the study subjects. According to the numerical random expression method, the admission serial number of all patients were randomly assigned to 2 groups, with 49 cases in each group. The control group received general anesthesia, and the observation group received ropivacaine local infiltration anesthesia combined with general anesthesia. Before anesthesia (T1), immediately after operation (T2), 30 minutes after operation (T3), 1 hour after operation (T4) and 6 hours after operation (T5), stress response and postoperative pain were compared between the two groups.

There was no significant difference in NE, E, MAP and HR between the two groups during T1 and T2 (P>0.05). From T3 to T5, NE, E, MAP and HR in the observation group were significantly lower than those in the control group (P<0.05). There were no significant differences in cytokine IL-6, CRP and WBC between the two groups before operation (P>0.05). The postoperative level of cytokine indicators IL-6, CRP and WBC of the observation group were significantly lower than those of the control group (P<0.05). The NRS score of the observation group was significantly lower than that of the control group at 6 h to 72 h after surgery (P<0.05).

The application of ropivacaine local infiltration anesthesia combined with general anesthesia in laparoscopic TEP can effectively inhibit perioperative stress response of patients, reduce inflammatory cytokine indicators and relieve postoperative pain, which is worthy of clinical promotion.