Comparison of anesthetic effect and blood gas influence between sevoflurane and propofol in the operation of inguinal hernia in children

doi:10.3877/cma.j.issn.1674-392X.2019.03.012

Abstract

Abstract:

Objective

To compare the anesthetic effect and blood gas influence between sevoflurane (S) and propofol (P) in the operation of inguinal hernia in children.

Methods

52 cases of inguinal hernia in general surgery of Dongtai People's hospital from January 2016 to May 2018 were randomly divided into the SR group (26 cases) and the PR group (26 cases). All patients received selective surgery, sevoflurane and remifentanil (R) were used for maintenance of anesthesia in the SR group, while propofol and remifentanil were used for maintenance of anesthesia in the PR group. Respiratory recovery time, awakening time, blood gas analysis index, hemodynamic index and incidence of anesthesia complications were compared between the two groups.

Results

There was no significant difference in the recovery time of breathing and awakening time between the two groups (P>0.05). At 10 minutes after anesthesia, the levels of PaO₂, SBP, DBP and HR decreased, while the level of PCO₂ increased (P<0.05), but there was no significant difference in the changes of SaO₂ in the two groups (P>0.05). Compared with preoperative, the levels of PaO₂, SBP, DBP and HR decreased at skin incision cutting and, while the level of PaCO₂ increased in the two groups (P<0.05), but there was no significant difference in the changes of SaO₂ (P>0.05). The levels of SBP and DBP in the PR group were higher than those in the SR group (P<0.05), but there was no significant difference in the level of HR (P>0.05). The incidence of restlessness in the SR group (38.46%) was higher than that in the PR group (11.54%) (P<0.05); there was no malignant vomiting in both groups, and there was no significant difference in the incidence of severe cough between the two groups (P>0.05).

Conclusion

SR and PR have certain effects on respiratory function and hemodynamics in children undergoing inguinal hernia surgery. R anesthesia has less effect on hemodynamic parameters such as SBP and DBP in children than P, but the incidence of restlessness after R anesthesia is higher. Both of them are effective drugs for pediatric anesthesia. The clinical specimens should be enlarged for further research and application.

Key words: Hernia, inguinal, Child, Blood gas, Hemodynamics, Complications

Yao Jiang. Comparison of anesthetic effect and blood gas influence between sevoflurane and propofol in the operation of inguinal hernia in children[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2019, 13(03): 238-242.

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References 22

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组别	例数	呼吸恢复时间	清醒时间
SR组	26	4.90±1.02	7.61±1.24
PR组	26	5.21±1.09	7.33±1.17
t值		1.059	0.837
P值		0.295	0.406

组别	例数	呼吸恢复时间	清醒时间
SR组	26	4.90±1.02	7.61±1.24
PR组	26	5.21±1.09	7.33±1.17
t值		1.059	0.837
P值		0.295	0.406

时间	组别	例数	PaO₂(kPa)	PaCO₂(kPa)	SaO₂(%)
术前	SR组	26	11.31±2.38	3.72±1.08	99.51±10.54
	PR组	26	11.29±2.37	3.74±1.11	99.50±10.31
	t值		0.030	0.066	0.003
	P值		0.976	0.948	0.997
麻醉后10 min	SR组	26	10.57±2.06^a	7.23±0.98^a	98.64±11.02
	PR组	26	10.61±2.13^a	7.24±0.95^a	98.67±10.95
	t值		0.069	0.037	0.010
	P值		0.945	0.970	0.992
切皮	SR组	26	9.24±1.71^a	7.41±1.02^a	98.92±10.53
	PR组	26	9.26±1.69^a	7.42±1.04^a	98.77±10.49
	t值		0.042	0.035	0.051
	P值		0.966	0.972	0.959

时间	组别	例数	PaO₂(kPa)	PaCO₂(kPa)	SaO₂(%)
术前	SR组	26	11.31±2.38	3.72±1.08	99.51±10.54
	PR组	26	11.29±2.37	3.74±1.11	99.50±10.31
	t值		0.030	0.066	0.003
	P值		0.976	0.948	0.997
麻醉后10 min	SR组	26	10.57±2.06^a	7.23±0.98^a	98.64±11.02
	PR组	26	10.61±2.13^a	7.24±0.95^a	98.67±10.95
	t值		0.069	0.037	0.010
	P值		0.945	0.970	0.992
切皮	SR组	26	9.24±1.71^a	7.41±1.02^a	98.92±10.53
	PR组	26	9.26±1.69^a	7.42±1.04^a	98.77±10.49
	t值		0.042	0.035	0.051
	P值		0.966	0.972	0.959

时间	组别	例数	SBP(mmHg)	DBP(mmHg)	HR(次/min)
术前	SR组	26	99.51±9.82	64.17±7.15	124.81±10.28
	PR组	26	97.27±9.79	64.51±7.21	124.39±10.17
	t值		0.824	0.171	0.148
	P值		0.414	0.865	0.883
麻醉后10 min	SR组	26	85.27±8.14^a	55.91±6.02^a	109.35±9.86^a
	PR组	26	88.24±8.31^a	56.71±5.94^a	110.29±9.79^a
	t值		1.302	0.482	0.345
	P值		0.199	0.632	0.732
切皮	SR组	26	83.59±9.39^a	58.37±5.81^a	110.74±10.21^a
	PR组	26	88.93±8.96^a	62.28±6.12^a	111.35±10.29^a
	t值		2.098	2.363	0.137
	P值		0.041	0.022	0.891

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