腹股沟疝是常见的普外科疾病，手术修补是腹股沟疝治愈的唯一方法。腹腔镜腹股沟疝修补术为主要的手术方式，随着微创理念和微创技术的发展，单孔腹腔镜腹股沟疝修补术也在不断的探索和实践中得到了发展和应用。本文通过3例病例报告阐述单孔腹腔镜完全腹膜外腹股沟疝修补术（SIL-TEP）在特殊解剖条件患者中的应用与优势。病例一为左侧腹股沟斜疝合并脐疝，伴有肝硬化失代偿、腹壁静脉曲张；病例二为右侧腹股沟直疝，有下腹部正中切口开腹手术史；病例三为左侧腹股沟直疝，有左下腹多个腔镜建孔手术史。3例病例的特殊解剖条件均增加了常规三孔腹腔镜腹股沟疝修补术行通道建立、空间分离等的操作难度，而SIL-TEP可优化腹腔镜腹股沟疝修补术特有的腹膜外路径和空间，能够安全、有效地完成伴有特殊解剖条件患者的腹股沟疝修补。

Inguinal hernia is a common general surgical disease, and surgical repair is the only way to cure inguinal hernia. Laparoscopic inguinal hernia repair is the main surgical method. With the development of minimally invasive concept and minimally invasive technology, single-incision laparoscopic inguinal hernia repair has also been developed and applied in continuous exploration and practice. This article describes the application and advantages of single-incision laparoscopic totally extra-peritoneal hernia repair (SIL-TEP) in patients with special anatomical conditions through three case reports. Case 1 was left indirect inguinal hernia combined with umbilical hernia with decompensated liver cirrhosis and abdominal wall varices. Case 2 was right direct inguinal hernia with a history of lower abdominal median incision laparotomy. Case 3 was left direct inguinal hernia with a history of left lower abdominal multiple endoscopic foramen operations. The special anatomical conditions of the three cases increased the difficulty of the conventional three-incision laparoscopic inguinal hernia repair, such as the establishment of channels and space separation. We can optimize the special extra-peritoneal route and space of laparoscopic inguinal hernia repair through SIL-TEP, and complete inguinal hernia repair safely and effectively in patients with special anatomical conditions.