探讨羟考酮复合舒芬太尼在腹腔镜疝修补术患者中应用效果。

回顾性分析2021年7月至2022年7月德驭医疗马鞍山总医院收治的80例腹股沟疝患者的临床资料，按照麻醉方式不同分为2组，各40例。对照组采用羟考酮联合丙泊酚＋顺式阿曲库铵进行麻醉，试验组在对照组的基础上联合使用舒芬太尼进行麻醉。分析2组患者的术中情况、麻醉效果视觉模拟评分、血流动力学、疼痛介质、不良反应指标。

2组患者的手术、麻醉时间比较，差异无统计学意义（P>0.05）。试验组苏醒时间少于对照组，差异有统计学意义[（9.72±4.49）min比（26.33±6.11）min，P<0.05]。2组患者的呼叫睁眼消失时间比较，差异无统计学意义（P>0.05）；对照组麻醉起效时间短于试验组，吞咽反射消失时间长于试验组，视觉模拟评分高于对照组患者低，差异有统计学意义[（8.98±1.86）min比（9.74±2.66）min，（4.98±0.59）min比（2.79±0.89）min，（3.33±1.56）分比（2.42±1.49）分；P<0.05]。术后8、12、24 h，试验组患者的平均动脉压、心率和呼吸频率均低于对照组，差异有统计学意义（P<0.05）；2组患者SpO₂水平比较，差异无统计学意义（P>0.05）。术前，2组患者的前列腺素E₂、5-羟色胺和P物质的表达水平比较，差异无统计学意义（P>0.05）；术后，2组患者的前列腺素E2、5-羟色胺和P物质表达水平均升高，但试验组的表达水平明显低于对照组，差异有统计学意义（P<0.05）。试验组嗜睡、低血压、呼吸抑制、呛咳等不良反应总发生率明显低于对照组，差异有统计学意义（P<0.05）。

羟考酮联合舒芬太尼麻醉应用于腹腔镜疝修补术患者，可有效改善患者疼痛评分，且对机体血流动力学及疼痛介质影响较小。

To explore the effects of oxycodone combined with sufentanil in patients undergoing laparoscopic hernia repair.

The clinical data of 80 patients with inguinal hernia admitted to Deyu Medical Ma'anshan General Hospital from July 2021 to July 2022 were retrospectively analyzed, and patients were divided into 2 groups according to different anesthesia methods, with 40 patients in each group. The control group was anesthetized with oxycodone combined with propofol+ cis-atracurium, and the experimental group was anesthetized with sufentanil on the basis of the control group. Intraoperative conditions, visual analogue scores (VAS) of anesthesia effects, hemodynamics, pain mediators, adverse reactions were analyzed between the 2 groups.

The operation and anesthesia time of patients in the 2 groups was not statistically significant (P>0.05). The awakening time of the experimental group was less than that of the control group, and the difference was statistically significant [(9.72±4.49) min vs (26.33±6.11) min, P<0.05]. There was no statistically significant difference in the disappearing time of the call to open the eyes of the patients between the 2 groups (P>0.05); The onset time of anesthesia in the control group was shorter than that in the experimental group, the disappearance time of swallowing reflex was longer than that in the experimental group, and the VAS score was higher than that of the control group patients, and the difference was statistically significant [(8.98±1.86) min vs (9.74±2.66) min, (4.98±0.59) min vs (2.79±0.89) min, (3.33±1.56) points vs (2.42±1.49) points; P<0.05]. At 8, 12, and 24 h after surgery, the mean arterial pressure, heart rate, and respiratory rate of patients in the experimental group were lower than those in the control group, and the difference was statistically significant (P<0.05); There was no significant difference in the SpO₂ levels of patients between the 2 groups (P>0.05). Before operation, the expression levels of prostaglandin E2, 5-hydroxytryptamine and substance P in the 2 groups of patients were not statistically significant (P>0.05); After operation, the expression levels of prostaglandin E2, 5-hydroxytryptamine and substance P between the 2 groups of patients were elevated, but the expression levels in the experimental group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions such as drowsiness, hypotension, respiratory depression, and choking in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05).

Oxycodone combined with sufentanil anesthesia in patients undergoing laparoscopic hernia repair effectively improves patients' pain scores with less impact on body hemodynamics and pain mediators.